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KMID : 1150820210340020045
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Anatomy & Biological Anthropology
2021 Volume.34 No. 2 p.45 ~ p.52
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Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model
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Piao Chun Hua
Fan Yan Jing
Nguyen Thi Van
Yu Zhen Nan
Shin Hee-Soon
Song Chang-Ho
Chai Ok-Hee
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Abstract
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Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi on ovalbumin (OVA)-induced mouse asthma model. In this study, we examined the effect of F. amomi on OVA-induced asthma by analyzing Th1/Th2 cytokine production, histopathologic changes, and focusing on the NF-κB signaling. Oral administration of F. amomi reduced the number of inflammatory cells especially eosinophils and improved airway and pulmonary inflammation in the lungs of OVA-challenged mice. In addition, F. amomi significantly downregulated the overproduction of tumor necrosis factor-α, IL-1β, IL-4, IL-5 and the levels of OVA-specific both IgE and IgG1 and increased the secretion of interferon-γ and OVA-specific IgG2a. Moreover, F. amomi suppressed the increase of total NF-κB level and the phosphorylation of IκB-α and NF-κB by OVA. F. amomi may have therapeutic effect for allergic asthma by modulating Th1/Th2 cytokine imbalance and inhibiting NF-κB signaling activation.
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KEYWORD
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Frutus amomi, Asthma, Th1/Th2 cytokine imbalance, OVA-specific IgE/IgG1/IgG2, NF-κB signaling
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